A hotkey to toggle save mods all at once

What is the simple hot key that toggles all saved mods on/off in any game? There has to be one, right? I can not for the life of me figure it out. It is quite frustrating when the game won’t let you progress, and you don’t know which mod is affecting the gameplay. I want to turn them all off in this situation. I’m tired of reloading and trying to figure it all out. Takes a ton of time.